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The end of Alzheimer’s

Expert in neurodegenerative diseases Dr Dale Bredeson joins us on Brain Awareness Week for a crucial Q&A.

Heights
March 16, 2021
5 min read

In this Braincare Clubhouse session, we discussed the possible causes of neurodegenerative diseases and the issues with how society approaches them.

  • Peter Ward: Co-Founder and CEO of Humanity.

  • Dale Bredesen: Internationally recognized as an expert in the mechanisms of neurodegenerative diseases. 

  • Tamsin Lewis: Former pro athlete and MD lifestyle and performance medicine. 

  • Dr Tommy Wood: University of Washington research assistant professor.

  • Xavier Louis: Co-Founder and CEO of SharpTX.

  • Dan Murray-Serter: Co-Founder of braincare company Heights, and host of our Braincare Podcast.

(Resources can be found at the bottom.) 


In the US, 500,000 people have died so far from COVID-19. Multiplying that number by 100 will give you the amount of Americans who will die of Alzheimer's. 

It's a massive pandemic with no vaccine.

The problem is that there hasn’t been an accurate model of Alzheimer’s. The research was about things like reactive oxygen species, misfolded proteins, tau, prions, type 3 diabetes, so on and so forth. This is fundamentally an insufficiency of the support of a neural network for plasticity. It takes 20 years for those who start developing Alzheimer’s to reach a diagnosis.

When you look at any health outcome, socioeconomic status and social deprivation are some of the best predictors of any of the risk factors for cognitive decline. Environmental and lifestyle factors play a key role. There are huge swathes of the population who don't have access to apps like Clubhouse, don't have the money to pay for ketosis or diagnostic tests, and they're the ones who are potentially at the greatest risk. There is an increasing reckoning for how systemic factors play a massive role in health.

Step 1: Understanding the nature of the problem

This has been one of the major issues. People are trying to develop a drug that works in order to see what Alzheimer’s is. Instead, we need to find out what chemistry drives the process and what chemistry fixes the process.

Step 2: Global program 

We need a global program to reduce neurodegenerative diseases that is feasible and applicable to everyone. It should start with combating cognitive decline, but will ultimately impact things like Parkinson's which is hugely associated with toxins that so many of us are exposed to.

The Alzheimer’s equation

  1. Energetics. Your energetics can start to fail due to ketosis, low cerebral blood flow, nocturnal hypoxemia, etc. 

  2. Trophic influences. Things like insulin resistance put you at increased risk of your brain-derived neurotrophic factor. 

  3. Toxin exposure. For example, metallic toxins.

  4. Anything that produces chronic inflammation. 

Diet and Toxins 

With respect to our diets, we’ve gone from having very high fiber diets to very low fiber diets.

We encourage people to get at least above 30 grams of fiber per day. It makes a big difference.

Toxins unquestionably increase your risk for cognitive decline. A study published in 2016 showed that 13% of the 9/11 World Trade Center responders have developed cognitive decline.

Make sure you have a clean water source and eat organic vegetables. By just eating the wrong things, you’re exposing yourself to many toxins. Unfortunately, we live in a toxic world.

You need to be doing these things in order to prevent cognitive decline and developing a neurodegenerative disease. 

Q&A

What supplements do you recommend?

Most of us are deficient in vitamin B, vitamin D, magnesium, zinc, iodine, and omega-3’s. Make sure you’re getting an appropriate omega-6 to omega-3 ratio.

By our 70’s, 1 in 5 of us will suffer cognitive impairment. As we age, our brain atrophies but the shrinking is accelerated with people suffering from Alzheimer's disease. If we could slow down the rate of brain loss, we could slow down this conversion to Alzheimer's disease.  

Homocysteine is a risk factor for brain atrophy, cognitive impairment, and dementia. Our body can detoxify homocysteine using three vitamins: folate, vitamin B12, and vitamin B6.

A study conducted by Professor David Smith at Oxford University found that a high dosage of vitamin B and omega-3 slowed the rate of brain shrinkage, thereby helping in the prevention of Alzheimer’s and dementia. 

Is Alzheimer’s genetic?

Familial Alzheimer’s disease (FAD) accounts for 5% of cases. 

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Is Alzheimer’s more prevalent in women?

Alzheimer’s disease is twice as common in women. If you look at all Alzheimer’s patients, about 65% of patients are women and fun fact- 60% of caregivers are also women.

Hormones seem to be an important part of this. There is a tremendous increase in people with perimenopause, menopause, and high toxicity levels experiencing cognitive decline. They often present differently with things like executive dysfunction, organizational problems, issues with word-finding, and problems with language capabilities and facial recognition. This is an unrecognized epidemic, and we need to be aware that it is more common in females than males.


Resources


Heights Smart Supplement contains the highest quality plant-based omega 3 DHA, EPA, along with 18 other key nutrients your brain needs to thrive according to science in just 2 capsules a day.

Want to host a room in Braincare club? Find out how here.

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